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  • The dosage form available for Testosterone Propionate is Injection Solution in cottonseed oil. Empower Pharmacy’s injection solutions are compounded under the stringent USP 797 guidelines for sterile compounding, and sterility, endotoxin, potency and pH testing is performed on every batch. Our quality-assurance process ensures the consistency and uniformity of every solution for injection we dispense.General Information Testosterone was the first successfully synthesized anabolic steroid. Testosterone propionate is a fast-acting, short-ester, oil-based injectable testosterone compound that is commonly prescribed for the treatment of hypogonadism – low testosterone levels and various related symptoms in males.During a series of experiments in 1935, testosterone propionate was first described in 1935 to increase synthetic testosterone’s therapeutic usefulness by slowing its release into the bloodstream.  It was released for clinical use two years later by Schering AG in Germany, featured in a hybrid blend with testosterone enanthate under the brand name Testoviron.  This was also the first commercially available version on the U.S. prescription drug market and remained the dominant form of testosterone globally prior to 1960. Mechanism of Action Endogenous testosterone is responsible for sexual maturation at all stages of development throughout life. Synthetically, it is prepared from cholesterol. The function of androgens in male development begins in the fetus, is crucial during puberty, and continues to play an important role in the adult male. Women also secrete small amounts of testosterone from the ovaries. The secretion of androgens from the adrenal cortex is insufficient to maintain male sexuality.Increased androgen plasma concentrations suppress gonadotropin-releasing hormone (reducing endogenous testosterone), luteinizing hormone, and follicle-stimulating hormone by a negative-feedback mechanism. Testosterone also affects the formation of erythropoietin, the balance of calcium, and blood glucose. Androgens have a high lipid solubility, enabling them to rapidly enter cells of target tissues. Within the cells, testosterone undergoes enzymatic conversion to 5-alpha-dihydrotestosterone and forms a loosely bound complex with cystolic receptors. Androgen action arises from the initiation of transcription and cellular changes in the nucleus brought about by this steroid-receptor complex.Pharmacokinetics Testosterone is administered intramuscularly (IM); via subcutaneous injection; to the skin as a topical gel, solution, ointment or transdermal systems for transdermal absorption; by implantation of long-acting pellets, or; via buccal systems.In serum, testosterone is bound to protein. It has a high affinity for sex hormone binding globulin (SHBG) and a low affinity for albumin. The albumin-bound portion freely dissociates. The affinity for SHBG changes throughout life. It is high during prepuberty, declines during adolescence and adult life, then rises again in old age. The active metabolite DHT has a greater affinity for SHBG than testosterone. Elimination half-life is 10—100 minutes and is dependent on the amount of free testosterone in the plasma.Testosterone is a substrate for CYP3A4 and is also both transported by and an inhibitor of P-glycoprotein (P-gp) transport. 1 3Route-Specific Pharmacokinetics Intramuscular Route : Parenteral testosterone formulations have been developed that reduce the rate of testosterone secretion, with esters being less polar and slowly absorbed from intramuscular sites. Esters have a duration of action of 2—4 weeks following IM administration. The esters are hydrolyzed to free testosterone, which is inactivated in the liver.Subcutaneous Route: The duration of action of testosterone subcutaneous implantable pellets (Testopel) is usually 3—4 months, but may last as long as 6 months.
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  • We prepare our farmland for cultivation by subsoiling, bottom plowing, analyzing the pH and micronutrient constituents and determining amendment requirements. Gardeners can have the same success if they employ similar techniques on a smaller scale. Applying compost in a variety of methods can solve a multitude of soil issues.
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  • Testosterone patches works by releasing the hormone testosterone through the skin into the bloodstream. In women, testosterone is naturally produced by the ovaries and the adrenal gland. However, levels of the hormone decline with age, sometimes more after menopause . [1] Testosterone therapy is systemic and needs to be applied over a period of weeks or months to have an effect. [2] P&G licensed the treatment to Watson Pharmaceuticals. [2]The amount of testosterone in the patch is lower than in testosterone patches for men. The patch is virtually transparent and about the size of an egg and is worn just below the navel and changed twice weekly. [1]The patch was granted a license from the European Medicines Agency in July, and is available on Britain s National Health Service from March 2007. It will initially only be available on prescription for post-menopausal women with diagnosed sexual problems. [1]However, in December 2004 the United States the 14-member Food and Drug Administration (FDA) advisory committee, plus voting consultants, for Reproductive Health Drugs unanimously rejected Procter and Gambles fast-track request for Intrinsa citing concerns about off-label use . In Canada, post-menopausal women have been able to obtain government-approved testosterone treatment since 2002. In Australia, post-menopausal women can use Organon testosterone implants which have to be surgically inserted and last from three to six months. [3]
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  • Testosterone is the primary male sex hormone and an anabolic steroid . In men, testosterone plays a key role in the development of male reproductive tissues such as the testis and prostate , as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair . [2] In addition, testosterone is essential for health and well-being, [3] and for the prevention of osteoporosis . [4] Insufficient levels of testosterone in men may lead to abnormalities including frailty and bone loss.Testosterone is also used as a medication to treat male hypogonadism and certain types of breast cancer . [5] Since testosterone levels gradually decrease as men age , synthetic testosterone is sometimes prescribed to older men to counteract this deficiency.Testosterone is a steroid from the androstane class containing a keto and hydroxyl groups at the three and seventeen positions respectively. It is biosynthesized in several steps from cholesterol and is converted in the liver to inactive metabolites. [6] It exerts its action through binding to and activation of the androgen receptor . [6]In humans and most other vertebrates , testosterone is secreted primarily by the testicles of males and, to a lesser extent, the ovaries of females . Small amounts are also secreted by the adrenal glands . On average, in adult males, levels of testosterone are about 7–8 times as great as in adult females. [7] As the metabolic consumption of testosterone in males is greater, the daily production is about 20 times greater in men. [8] [9] Females are also more sensitive to the hormone. [10]In general, androgens such as testosterone promote protein synthesis and thus growth of tissues with androgen receptors . [11] Testosterone can be described as having virilising and anabolic effects (though these categorical descriptions are somewhat arbitrary, as there is a great deal of mutual overlap between them). [12]Testosterone effects can also be classified by the age of usual occurrence. For postnatal effects in both males and females, these are mostly dependent on the levels and duration of circulating free testosterone.The first period occurs between 4 and 6 weeks of the gestation. Examples include genital virilisation such as midline fusion, phallic urethra , scrotal thinning and rugation , and phallic enlargement; although the role of testosterone is far smaller than that of dihydrotestosterone . There is also development of the prostate gland and seminal vesicles .During the second trimester, androgen level is associated with gender formation. [13] This period affects the femininization or masculinization of the fetus and can be a better predictor of feminine or masculine behaviours such as sex typed behaviour than an adults own levels. A mothers testosterone level during pregnancy is correlated with her daughters sex-typical behavior as an adult, and the correlation is even stronger than with the daughters own adult testosterone level. [14]Before puberty effects of rising androgen levels occur in both boys and girls. These include adult-type body odor , increased oiliness of skin and hair, acne , pubarche (appearance of pubic hair ), axillary hair (armpit hair), growth spurt , accelerated bone maturation , and facial hair . [19]Pubertal effects begin to occur when androgen has been higher than normal adult female levels for months or years. In males, these are usual late pubertal effects, and occur in women after prolonged periods of heightened levels of free testosterone in the blood. The effects include: [19] [20]
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  • Bien qu’il existe de nombreuses hormones, nous pouvons nous attarder sur l’importance de la testostérone en termes de fonction et de bonne santé, en particulier pour les hommes.Les hommes et les femmes ont besoin de testostérone pour faire fonctionner leur corps, mais les hommes ont besoin de quantités beaucoup plus élevées que leurs homologues de sexe féminin.Bien qu’elle soit une hormone très importante et largement incomprise , la testostérone est pourtant une des hormones les plus intéressantes à comprendre, surtout en ce qui concerne l’ amélioration des performances et du physique .En fait nous pouvons affirmer que c’est l’hormone la plus importante pour l’amélioration de la performance athlétique et le développement du corps et des muscles (musculation). Sans des niveaux adéquats de testostérone , nos objectifs ne seront pas atteints, et sans une augmentation artificielle des niveaux de l’hormone testostérone , vous pourrez dire adieu à l’idée de dépasser vos objectifs et pourquoi pas battre des records.Il sera donc intéressant d’avoir une compréhension générale de l’hormone en elle-même, et alors vous comprendrez comment maximiser son utilisation sous toutes ses formes.La testostérone appartient à la classe des hormones androgènes , en fait, c’est la principale hormone androgène du corps. C’est une hormone très puissante et la testostérone est en grande partie responsable du développement des testicules et de la prostate, ainsi que du développement du tissu musculaire , de la densité osseuse et de la force .De faibles niveaux de testostérone peuvent non seulement affecter négativement la force musculaire et la densité osseuse, mais peut aussi nuire à notre état d’esprit.Bien que faisant partie de la classe androgène des hormones stéroïdiennes, la testostérone est également fortement anabolique.À la fois anabolisante et androgène, la testostérone est comme toutes les hormones stéroïdiennes, elle est dérivée du cholestérol et sa production naturelle est largement régulée par les hormones lutéinisantes (LH) et les hormones folliculo-stimulante (FSH).Pour que ces hormones soient libérées, la glande pituitaire doit d’abord être stimulée, et une fois que LH et FSH sont libérés, la stimulation du testicule est obtenue, provoquant ainsi la production de la testostérone.
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  • Bien qu’il existe de nombreuses hormones, nous pouvons nous attarder sur l’importance de la testostérone en termes de fonction et de bonne santé, en particulier pour les hommes.Les hommes et les femmes ont besoin de testostérone pour faire fonctionner leur corps, mais les hommes ont besoin de quantités beaucoup plus élevées que leurs homologues de sexe féminin.Bien qu’elle soit une hormone très importante et largement incomprise , la testostérone est pourtant une des hormones les plus intéressantes à comprendre, surtout en ce qui concerne l’ amélioration des performances et du physique .En fait nous pouvons affirmer que c’est l’hormone la plus importante pour l’amélioration de la performance athlétique et le développement du corps et des muscles (musculation). Sans des niveaux adéquats de testostérone , nos objectifs ne seront pas atteints, et sans une augmentation artificielle des niveaux de l’hormone testostérone , vous pourrez dire adieu à l’idée de dépasser vos objectifs et pourquoi pas battre des records.Il sera donc intéressant d’avoir une compréhension générale de l’hormone en elle-même, et alors vous comprendrez comment maximiser son utilisation sous toutes ses formes.La testostérone appartient à la classe des hormones androgènes , en fait, c’est la principale hormone androgène du corps. C’est une hormone très puissante et la testostérone est en grande partie responsable du développement des testicules et de la prostate, ainsi que du développement du tissu musculaire , de la densité osseuse et de la force .De faibles niveaux de testostérone peuvent non seulement affecter négativement la force musculaire et la densité osseuse, mais peut aussi nuire à notre état d’esprit.Bien que faisant partie de la classe androgène des hormones stéroïdiennes, la testostérone est également fortement anabolique.À la fois anabolisante et androgène, la testostérone est comme toutes les hormones stéroïdiennes, elle est dérivée du cholestérol et sa production naturelle est largement régulée par les hormones lutéinisantes (LH) et les hormones folliculo-stimulante (FSH).Pour que ces hormones soient libérées, la glande pituitaire doit d’abord être stimulée, et une fois que LH et FSH sont libérés, la stimulation du testicule est obtenue, provoquant ainsi la production de la testostérone.
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  • Testosterone Cypionate, USP is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils.The chemical name for Testosterone Cypionate, USP is androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-. Its molecular formula is C 27 H 40 O 3 , and the molecular weight 412.61.Testosterone Cypionate Injection, USP is available in one strength, 200 mg/mL Testosterone Cypionate, USP.Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor.During exogenous administration of androgens, endogenous Testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.Testosterone in plasma is 98 percent bound to a specific Testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of Testosterone between free and bound forms, and the free Testosterone concentration will determine its half-life.About 90 percent of a dose of Testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of Testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of Testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways.In many tissues the activity of Testosterone appears to depend on reduction to dihydroTestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.Safety and efficacy of Testosterone cypionate in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”) have not been established.
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  • We prepare our farmland for cultivation by subsoiling, bottom plowing, analyzing the pH and micronutrient constituents and determining amendment requirements. Gardeners can have the same success if they employ similar techniques on a smaller scale. Applying compost in a variety of methods can solve a multitude of soil issues.
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  • Bien qu’il existe de nombreuses hormones, nous pouvons nous attarder sur l’importance de la testostérone en termes de fonction et de bonne santé, en particulier pour les hommes.Les hommes et les femmes ont besoin de testostérone pour faire fonctionner leur corps, mais les hommes ont besoin de quantités beaucoup plus élevées que leurs homologues de sexe féminin.Bien qu’elle soit une hormone très importante et largement incomprise , la testostérone est pourtant une des hormones les plus intéressantes à comprendre, surtout en ce qui concerne l’ amélioration des performances et du physique .En fait nous pouvons affirmer que c’est l’hormone la plus importante pour l’amélioration de la performance athlétique et le développement du corps et des muscles (musculation). Sans des niveaux adéquats de testostérone , nos objectifs ne seront pas atteints, et sans une augmentation artificielle des niveaux de l’hormone testostérone , vous pourrez dire adieu à l’idée de dépasser vos objectifs et pourquoi pas battre des records.Il sera donc intéressant d’avoir une compréhension générale de l’hormone en elle-même, et alors vous comprendrez comment maximiser son utilisation sous toutes ses formes.La testostérone appartient à la classe des hormones androgènes , en fait, c’est la principale hormone androgène du corps. C’est une hormone très puissante et la testostérone est en grande partie responsable du développement des testicules et de la prostate, ainsi que du développement du tissu musculaire , de la densité osseuse et de la force .De faibles niveaux de testostérone peuvent non seulement affecter négativement la force musculaire et la densité osseuse, mais peut aussi nuire à notre état d’esprit.Bien que faisant partie de la classe androgène des hormones stéroïdiennes, la testostérone est également fortement anabolique.À la fois anabolisante et androgène, la testostérone est comme toutes les hormones stéroïdiennes, elle est dérivée du cholestérol et sa production naturelle est largement régulée par les hormones lutéinisantes (LH) et les hormones folliculo-stimulante (FSH).Pour que ces hormones soient libérées, la glande pituitaire doit d’abord être stimulée, et une fois que LH et FSH sont libérés, la stimulation du testicule est obtenue, provoquant ainsi la production de la testostérone.
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  • Testosterone enanthate ( USAN , BAN ) (brand names Delatestryl , Testostroval , Testro LA , Andro LA , Durathate , Everone , Testrin , Andropository ), or testosterone heptanoate , is an androgen and anabolic steroid and a testosterone ester . [2] [3] [4] Along with testosterone cypionate and testosterone propionate , it is one of the most widely used testosterone esters. [5] Testosterone enanthate was first introduced in 1952. [6] Administered via intramuscular injection , it is the most widely used form of testosterone in androgen replacement therapy . [6]Testosterone enanthate has an elimination half-life of 4.5 days and a mean residence time of 8.5 days when used as a depot intramuscular injection. [1] It requires frequent administration of approximately once per week, and large fluctuations in testosterone levels result with it, with levels initially being elevated and supraphysiological. [1]
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  • All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
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  • Primary androgen in humans synthesized by testes, ovaries, and adrenal cortex; available in a variety of dosage forms Used primarily for androgen replacement in males with hypogonadism due to medical conditions FDA warns against use for low testosterone status exclusively due to aging due to potential cardiovascular riskAndro-L.A., Androderm, AndroGel, Aveed, AXIRON, Delatestryl, Depo-Testosterone, First - Testosterone, First - Testosterone MC, FORTESTA, Natesto, STRIANT, Testim, Testopel, Virilon, VogelxoAndroderm Transdermal Film ER: 2mg, 4mg, 24h AndroGel/FORTESTA/Testim/Testosterone/Vogelxo Transdermal Gel: 0.5g, 1%, 1.62%, 10mg Andro-L.A./Aveed/Delatestryl/Depo-Testosterone/Testosterone Cypionate/Testosterone Enanthate/Virilon Intramuscular Inj Sol: 1mL, 100mg, 200mg, 250mg AXIRON/First - Testosterone/First - Testosterone MC Topical Sol: 1.5mL, 2%, 30mg Natesto Nasal Gel: 1actuation, 5.5mg STRIANT Buccal Tab ER: 30mg STRIANT Transmucosal Tab ER: 30mg Testopel Subcutaneous Imp: 75mgUp to 100 mg IM per month for a limited period, usually between 4—6 months. Different dosage schedules have been employed dependent on patients chronological and skeletal age, and response.Initially, 400 mg IM daily for one week, then 400 mg IM once or twice a week. Maintenance dose is 200—400 mg IM once every 4 weeks.Apply a 1% or 2% ointment topically to the vulva twice daily for six weeks or until itching is relieved. Decrease dosage to minimum effective dose.Generally, androgen use is contraindicated in patients with severe hepatic dysfunction. Specific guidelines for dosage adjustment in hepatic impairment are not available; use caution in patients with mild to moderate hepatic disease.Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed.Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Testosterone enanthate is a clear, colorless to pale yellow solution. For testosterone cypionate, warming and shaking the vial should re-dissolve any crystals that may have formed during storage at temperatures lower than recommended.Testosterone pellets are for subcutaneous implantation. Pellets may extrude or migrate from the insertion site if superficially implanted or if aseptic technique is not used.
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  • All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
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  • Testosterone enanthate ( USAN , BAN ) (brand names Delatestryl , Testostroval , Testro LA , Andro LA , Durathate , Everone , Testrin , Andropository ), or testosterone heptanoate , is an androgen and anabolic steroid and a testosterone ester . [2] [3] [4] Along with testosterone cypionate and testosterone propionate , it is one of the most widely used testosterone esters. [5] Testosterone enanthate was first introduced in 1952. [6] Administered via intramuscular injection , it is the most widely used form of testosterone in androgen replacement therapy . [6]Testosterone enanthate has an elimination half-life of 4.5 days and a mean residence time of 8.5 days when used as a depot intramuscular injection. [1] It requires frequent administration of approximately once per week, and large fluctuations in testosterone levels result with it, with levels initially being elevated and supraphysiological. [1]
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  • Primary androgen in humans synthesized by testes, ovaries, and adrenal cortex; available in a variety of dosage forms Used primarily for androgen replacement in males with hypogonadism due to medical conditions FDA warns against use for low testosterone status exclusively due to aging due to potential cardiovascular riskAndro-L.A., Androderm, AndroGel, Aveed, AXIRON, Delatestryl, Depo-Testosterone, First - Testosterone, First - Testosterone MC, FORTESTA, Natesto, STRIANT, Testim, Testopel, Virilon, VogelxoAndroderm Transdermal Film ER: 2mg, 4mg, 24h AndroGel/FORTESTA/Testim/Testosterone/Vogelxo Transdermal Gel: 0.5g, 1%, 1.62%, 10mg Andro-L.A./Aveed/Delatestryl/Depo-Testosterone/Testosterone Cypionate/Testosterone Enanthate/Virilon Intramuscular Inj Sol: 1mL, 100mg, 200mg, 250mg AXIRON/First - Testosterone/First - Testosterone MC Topical Sol: 1.5mL, 2%, 30mg Natesto Nasal Gel: 1actuation, 5.5mg STRIANT Buccal Tab ER: 30mg STRIANT Transmucosal Tab ER: 30mg Testopel Subcutaneous Imp: 75mgUp to 100 mg IM per month for a limited period, usually between 4—6 months. Different dosage schedules have been employed dependent on patients chronological and skeletal age, and response.Initially, 400 mg IM daily for one week, then 400 mg IM once or twice a week. Maintenance dose is 200—400 mg IM once every 4 weeks.Apply a 1% or 2% ointment topically to the vulva twice daily for six weeks or until itching is relieved. Decrease dosage to minimum effective dose.Generally, androgen use is contraindicated in patients with severe hepatic dysfunction. Specific guidelines for dosage adjustment in hepatic impairment are not available; use caution in patients with mild to moderate hepatic disease.Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed.Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Testosterone enanthate is a clear, colorless to pale yellow solution. For testosterone cypionate, warming and shaking the vial should re-dissolve any crystals that may have formed during storage at temperatures lower than recommended.Testosterone pellets are for subcutaneous implantation. Pellets may extrude or migrate from the insertion site if superficially implanted or if aseptic technique is not used.
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  • We prepare our farmland for cultivation by subsoiling, bottom plowing, analyzing the pH and micronutrient constituents and determining amendment requirements. Gardeners can have the same success if they employ similar techniques on a smaller scale. Applying compost in a variety of methods can solve a multitude of soil issues.
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  • We prepare our farmland for cultivation by subsoiling, bottom plowing, analyzing the pH and micronutrient constituents and determining amendment requirements. Gardeners can have the same success if they employ similar techniques on a smaller scale. Applying compost in a variety of methods can solve a multitude of soil issues.
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  • All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
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  • Testosterone patches works by releasing the hormone testosterone through the skin into the bloodstream. In women, testosterone is naturally produced by the ovaries and the adrenal gland. However, levels of the hormone decline with age, sometimes more after menopause . [1] Testosterone therapy is systemic and needs to be applied over a period of weeks or months to have an effect. [2] P&G licensed the treatment to Watson Pharmaceuticals. [2]The amount of testosterone in the patch is lower than in testosterone patches for men. The patch is virtually transparent and about the size of an egg and is worn just below the navel and changed twice weekly. [1]The patch was granted a license from the European Medicines Agency in July, and is available on Britain s National Health Service from March 2007. It will initially only be available on prescription for post-menopausal women with diagnosed sexual problems. [1]However, in December 2004 the United States the 14-member Food and Drug Administration (FDA) advisory committee, plus voting consultants, for Reproductive Health Drugs unanimously rejected Procter and Gambles fast-track request for Intrinsa citing concerns about off-label use . In Canada, post-menopausal women have been able to obtain government-approved testosterone treatment since 2002. In Australia, post-menopausal women can use Organon testosterone implants which have to be surgically inserted and last from three to six months. [3]
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